Oestrogel contains estradiol, which is identical to the estrogen hormone produced naturally in the body. Therefore, Oestrogel is considered a bioidentical hormone preparation.
Bioidentical hormones are hormones that are structurally identical to those found naturally in the human body. They are derived from plant sources and are engineered in the lab to have the same molecular structure as endogenous human hormones like estrogen, progesterone and testosterone.
The key difference between bioidentical and synthetic hormones is the molecular structure. Synthetic hormones like ethinyl estradiol found in birth control pills have a different molecular structure than natural estrogen. As a result, they can bind differently to hormone receptors in the body and cause different effects.
On the other hand, bioidentical estradiol binds to estrogen receptors in the same way as naturally produced estrogen. This gives it the advantage of having more natural hormonal activity in the body.
Some key facts about Oestrogel:
- The active ingredient is 17β-estradiol, which is chemically identical to estrogen produced by the ovaries.
- It comes in a gel form that is absorbed through the skin when applied. This avoids first-pass metabolism by the liver.
- It is available in multiple concentrations like 0.06%, 1.25% etc which allow customized dosing based on a woman's needs.
- When applied correctly, Oestrogel delivers estradiol into the bloodstream within 5 minutes. This allows prompt relief of menopausal symptoms.
Oestrogel is prescribed for:
- Treatment of moderate to severe vasomotor symptoms like hot flashes and night sweats associated with menopause.
- Prevention of postmenopausal osteoporosis or bone loss. Estrogen plays a key role in maintaining healthy bone density.
- Treatment of moderate to severe symptoms of vulvar and vaginal atrophy like dryness, irritation, itching and painful intercourse.
The benefits of using Oestrogel include:
- As a bioidentical hormone, it provides estrogen activity that closely mimics natural estrogen produced by the body.
- Transdermal gel provides more stable hormone levels compared to patches.
- Lower risk of side effects like thromboembolism and vaginal bleeding compared to synthetic estrogen.
- Customizable dosing options to meet individual needs. The amount of gel applied can be increased or decreased as needed.
- Improved patient compliance because gels are easy to use on a daily basis.
However, like any medication, Oestrogel too can have certain risks and side effects. The most common ones include:
- Skin irritation, redness or rash at the application site. This is usually mild and resolves quickly on its own. Using a moisturizer before application can help.
- Headaches, breast tenderness, nausea in some women initially. These effects are transient.
- Increased risk of endometrial hyperplasia if used without progesterone in women with intact uterus.
- Interactions with other drugs that are metabolized by the CYP3A4 liver enzyme. Dose adjustments may be required.
In summary, Oestrogel contains natural bioidentical 17β-estradiol which is chemically identical to estrogen produced by the woman's body. It is an effective way to deliver the benefits of estrogen replacement with minimal risks. Speak to your doctor to see if Oestrogel is an appropriate option to manage your menopausal symptoms.
At Balance Hormone Center, we specialize in treating hormonal imbalances with bioidentical hormone therapy customized to your needs. Our experienced physicians will evaluate your hormone levels and symptoms and work with you to create a personalized treatment plan using FDA-approved bioidentical hormones like Oestrogel. We also provide ongoing monitoring and dosage adjustments to help you achieve optimal hormonal balance. Contact us today to schedule a consultation.
