Angeliq HRT is a combination of estradiol and drospirenone approved by the FDA for the treatment of moderate to severe vasomotor symptoms due to menopause in women who have an intact uterus. The estradiol in Angeliq is a bioidentical form of estrogen that is identical to the estrogen produced naturally in the body. The drospirenone in Angeliq is a progestin that helps protect the uterus from overgrowth that can occur with unopposed estrogen therapy.
Overall, data shows Angeliq to be generally safe and effective when used as prescribed under the care of a healthcare provider. The potential benefits of Angeliq HRT include relief of hot flashes and night sweats, prevention of bone loss, and reduced fracture risk. These benefits are weighed against the potential risks.
The most common side effects of Angeliq are breast tenderness, headache, swelling or fluid retention, stomach/abdominal cramps, bloating, and nausea. More serious risks may include blood clots, stroke, heart attack, gallbladder disease, and rarely certain types of cancers. However, the progestin drospirenone in Angeliq carries less risk of blood clots compared to older progestins. All risks are greater in women who smoke, have uncontrolled high blood pressure, diabetes, high cholesterol, or obesity.
Here are some key points about the safety of Angeliq HRT:
- Angeliq contains bioidentical estradiol, which is identical to the estrogen made naturally by the body. Bioidentical hormones are generally safer with fewer side effects compared to synthetic hormones.
- Clinical trials found no increased risk of breast cancer with Angeliq use for up to 5 years. Rates of breast cancer were actually lower compared to placebo. However, there are still uncertainties about breast cancer risk with long-term use beyond 5 years.
- Studies found no increased risk of heart disease or stroke with Angeliq. The progestin drospirenone may have favorable effects on blood pressure, cholesterol, and blood clotting.
- Women over age 60 or who are more than 10 years past menopause may have a slightly increased risk of dementia with Angeliq use, according to some studies. More research is needed.
- Angeliq is not recommended for women with liver disease, undiagnosed vaginal bleeding, history of certain cancers, blood clots, stroke, heart disease, or uncontrolled high blood pressure.
- When used exactly as prescribed, Angeliq appears safe for most healthy women under age 60 within 10 years of menopause who do not have contraindications. However, risks and benefits must always be carefully weighed by each individual woman and their healthcare provider.
- It's important for women to have regular follow-up with their healthcare provider while using Angeliq HRT. Doctors should monitor for any potential side effects and conduct necessary screening tests such as mammograms.
Overall, the research suggests Angeliq can provide effective relief for menopausal symptoms when used appropriately under medical supervision. As with any medication, the benefits must be balanced with the potential risks for each woman. Proper screening and monitoring by a healthcare professional is important for safe use.
Women seeking customized guidance about Angeliq or alternatives for managing menopause may benefit from speaking with the specialists at Balance Hormone Center, a leading hormone therapy clinic. Their team of experienced physicians and nurse practitioners can provide thorough risk assessment, education, and ongoing monitoring to help women make informed decisions about hormonal options for safe and effective symptom relief during menopause. Contact Balance Hormone Center today to learn more and schedule a consultation.
